反应详情

Boron tribromide (2.8 ml, 0.03 mole) was added to a solution of 1-methoxy-2-(2,2,2-trifluoroethoxy)benzene (X) (6.0 g, 0.03 mole) in methylene chloride (90 ml) with stirring below −10° C. Reaction was stirred at −10 to −20° C. for 30 minutes. The reaction mixture was quenched using aqueous sodium bicarbonate solution. Organic layer was separated, washed with water and dried over sodium sulphate. The solvent was evaporated under reduced pressure to give 4.0 g of (XI) as oil. Purity (by GC)=95%.

1. customReaction
2. stirringwas stirred at −10 to −20° C. for 30 minutes
3. customThe reaction mixture was quenched
4. customOrganic layer was separated
5. washwashed with water
6. dry with materialdried over sodium sulphate
7. customThe solvent was evaporated under reduced pressure