反应详情

温度

2.5 °C

To a solution of 1.4 g of (4R,6S)-6-(dimethoxymethyl)-tetrahydro-2H-pyran-2,4-diol (I′) in 100 mL of water, 2.4 g of barium carbonate and 0.5 mL of bromine at 0° C. are added. After 3 hours of stirring at 0-5° C., the product II′ is extracted three times with 300 mL of ethyl acetate. Finally ethyl acetate is distilled off. The residue is flash chromatographed (DIPE/acetonitrile 2/1). The solvents are distilled off to get the title compound.

1. extractionthe product II′ is extracted three times with 300 mL of ethyl acetate
2. distillationFinally ethyl acetate is distilled off
3. customchromatographed (DIPE/acetonitrile 2/1)
4. distillationThe solvents are distilled off