HCID 67092836, compound → HCID 67093126, compound

Participants

Reaction Steps

A solution of (3S,6S,8aR)-7-benzyl-3-[2-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-ethyl]-6,8a-dimethyl-hexahydro-oxazolo[3,2-a]pyrazin-5-one (160 mg, 0.39 mmol) in EtOH (3 mL) was stirred at 50° C. for 3 h under a hydrogen atmosphere (3 bar) in the presence of palladium (10% on activated charcoal, 63 mg), then insoluble material was removed by filtration through diatomaceous earth. The filtrate was evaporated to afford the title compound (104 mg, 83%). Off-white foam, MS: 324.5 (M+H)+.

Provenance & Evidence