HRID1261843

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11829415

未命名化合物

结构：C[C@H]1C(=O)N2C(CN1C(=O)OCc1ccccc1)OCCC[C@H]2CO

HCID67093093

未命名化合物

结构：COC(=O)[C@H](C)N(CC=O)C(=O)OCc1ccccc1

HCID86638111

未命名化合物

2 次

PRODUCTS

生成物

结构：C[C@H]1C(=O)N2C(CN1C(=O)OCc1ccccc1)OC[C@@H]2CCCO

HCID67092675

7H-Oxazolo[3,2-a]pyrazine-7-carboxylic acid, hexahydro-3-(3-hydroxypropyl)-6-methyl-5-oxo-, phenylmethyl ester, (3S,6S)-

C18H24N2O5

PROCEDURE

实验过程

Condensation of (S)-2-[benzyloxycarbonyl-(2-oxo-ethyl)-amino]-propionic acid methyl ester (intermediate 1) with (S)-2-amino-pentane-1,5-diol in analogy with examples 1/2F produced a nearly statistical mixture of the title compound [light yellow gum, MS: 349.3 (M+H)+] and (3S,5S)-5-hydroxymethyl-3-methyl-4-oxo-octahydro-9-oxa-2,4a-diaza-benzocycloheptene-2-carboxylic acid benzyl ester [light yellow gum, MS:349.3 (M+H)|], which were separated by column chromatography (SiO2; DCM→DCM/MeOH/25% aq. ammonia solution 90:10:0.25).

WORKUP

后处理

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