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HRID1261844

反应详情

EQUATION

反应方程式

HRID 1261844 的结构方程式

REACTANTS

反应物

3
结构：C[C@H]1C(=O)N2[C@@H](CCC(=O)N3CCC4(CC4)[C@H](O)C3)CO[C@H]2CN1C(=O)OCc1ccccc1
HCID67092672

未命名化合物

结构：N[C@H](CO)CCC(=O)N1CCC2(CC2)[C@H](O)C1
HCID67092882

未命名化合物

结构：COC(=O)[C@H](C)N(CC=O)C(=O)OCc1ccccc1
HCID86638111

未命名化合物

2 次

PRODUCTS

生成物

1
结构：C[C@H]1C(=O)N2[C@@H](CCC(=O)N3CCC4(CC4)[C@H](O)C3)CO[C@@H]2CN1C(=O)OCc1ccccc1
HCID67092668

未命名化合物

PROCEDURE

实验过程

Condensation of (S)-2-[benzyloxycarbonyl-(2-oxo-ethyl)-amino]-propionic acid methyl ester (intermediate 1) with (S)-4-amino-5-hydroxy-1-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-pentan-1-one in analogy with examples 1/2F produced a nearly statistical mixture of the title compound [light brown gum, MS: 472.4 (M+H)+], and its epimer, (3S,6S,8aS)-3-[3-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-3-oxo-propyl]-6-methyl-5-oxo-hexahydro-oxazolo[3,2-a]pyrazine-7-carboxylic acid benzyl ester [light brown gum, MS: 472.4 (M+H)|], which were separated by column chromatography (SiO2; DCM→DCM/MeOH/25% aq. ammonia solution 90:10:0.25).

WORKUP

后处理

  1. customproduced