Potassium Carbonate → HCID 67093153, compound

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Reaction Steps

A solution of (S)-2-allyl-5-{[benzyloxycarbonyl-((S)-1-methoxycarbonyl-ethyl)-amino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester (298 mg, 0.65 mmol) in hydrogen chloride solution (4 M in 1,4-dioxane, 3 mL) was stirred at room temperature for 2 h, then evaporated. The residue was taken up in MeOH (3 mL), then after addition of potassium carbonate (268 mg, 1.94 mmol) the suspension was stirred at room temperature for 16 h, then partitioned between sat. aq. ammonium chloride solution and EtOAc. The organic layer was washed with brine, dried over magnesium sulfate, and evaporated to afford the title compound (221 mg, 100%). Light brown solid, MS: 329.4 (M+H)+.

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