HCID 51040483, compound → HCID 178491471, compound

HRID 1261864Notes

Reaction equation

HRID 1261864 reaction equation
[C:1]([CH2:3][CH2:4][PH:5](O[C@@H]1[C@@H](COC(C2C=CC=CC=2)(C2C=CC(OC)=CC=2)C2C=CC(OC)=CC=2)O[C@@H](N2C=CC(=O)NC2=O)[C@@H]1OCOCC(C(F)(F)F)C(F)(F)F)([N:7]([CH:11]([CH3:13])[CH3:12])[CH:8]([CH3:10])[CH3:9])[OH:6])#[N:2].[C:66]([NH:69][C:70]1[C:71]2[N:72]=[CH:73][N:74]([C:119]=2[N:120]=[CH:121][N:122]=1)[C@@H:75]1[O:118][C@H:92]([CH2:93][O:94][C:95]([C:112]2[CH:117]=[CH:116][CH:115]=[CH:114][CH:113]=2)([C:104]2[CH:109]=[CH:108][C:107]([O:110][CH3:111])=[CH:106][CH:105]=2)[C:96]2[CH:101]=[CH:100][C:99]([O:102][CH3:103])=[CH:98][CH:97]=2)[C@@H:90]([OH:91])[C@H:76]1[O:77][CH2:78][O:79][CH2:80][CH:81]([C:86]([F:89])([F:88])[F:87])[C:82]([F:85])([F:84])[F:83])(=[O:68])[CH3:67]>>[C:1]([CH2:3][CH2:4][PH:5]([O:91][C@@H:90]1[C@@H:92]([CH2:93][O:94][C:95]([C:112]2[CH:113]=[CH:114][CH:115]=[CH:116][CH:117]=2)([C:104]2[CH:109]=[CH:108][C:107]([O:110][CH3:111])=[CH:106][CH:105]=2)[C:96]2[CH:97]=[CH:98][C:99]([O:102][CH3:103])=[CH:100][CH:101]=2)[O:118][C@@H:75]([N:74]2[C:119]3[N:120]=[CH:121][N:122]=[C:70]([NH:69][C:66](=[O:68])[CH3:67])[C:71]=3[N:72]=[CH:73]2)[C@@H:76]1[O:77][CH2:78][O:79][CH2:80][CH:81]([C:82]([F:83])([F:84])[F:85])[C:86]([F:89])([F:88])[F:87])([N:7]([CH:11]([CH3:13])[CH3:12])[CH:8]([CH3:9])[CH3:10])[OH:6])#[N:2]

Participants

3

Reactant 2

HCID 51040483HCID 51040483, compoundHCID 178491469HCID 178491469, compound

Product 1

HCID 178491471HCID 178491471, compoundYield 70%

Procedure

This compound was synthesized in the same manner as that used for the compound 3u by using the compound 2a instead of the compound 2u. Yield was 70% (white foam).

Workup

  1. customThis compound was synthesized in the same manner as

Sources & evidence

ORD record
ord-18887a1eb3d4457d89dcc66ef98bb02b
Source dataset
uspto-grants-2013_06
Patent number
US08470987B2

Reaction notes

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