HCID 86655994, compound → HCID 178491467, compound

HRID 1261865Notes

Reaction equation

HRID 1261865 reaction equation
[C:1]([CH2:3][CH2:4][PH:5]([O:14][C@@H:15]1[C@@H:19]([CH2:20][O:21][C:22]([C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=2)([C:31]2[CH:36]=[CH:35][C:34]([O:37][CH3:38])=[CH:33][CH:32]=2)[C:23]2[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][CH:24]=2)[O:18][C@@H:17]([N:45]2[CH:52]=[CH:51][C:49](=O)[NH:48][C:46]2=[O:47])[C@@H:16]1[O:53][CH2:54][O:55][CH2:56][CH:57]([C:62]([F:65])([F:64])[F:63])[C:58]([F:61])([F:60])[F:59])([N:7]([CH:11]([CH3:13])[CH3:12])[CH:8]([CH3:10])[CH3:9])[OH:6])#[N:2].[C:66]([NH:69]C1C=CN([C@@H]2O[C@H](COC(C3C=CC=CC=3)(C3C=CC(OC)=CC=3)C3C=CC(OC)=CC=3)[C@@H](O)[C@H]2OCOCC(C(F)(F)F)C(F)(F)F)C(=O)N=1)(=[O:68])[CH3:67]>>[C:1]([CH2:3][CH2:4][PH:5]([O:14][C@@H:15]1[C@@H:19]([CH2:20][O:21][C:22]([C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=2)([C:23]2[CH:24]=[CH:25][C:26]([O:29][CH3:30])=[CH:27][CH:28]=2)[C:31]2[CH:32]=[CH:33][C:34]([O:37][CH3:38])=[CH:35][CH:36]=2)[O:18][C@@H:17]([N:45]2[CH:52]=[CH:51][C:49]([NH:69][C:66](=[O:68])[CH3:67])=[N:48][C:46]2=[O:47])[C@@H:16]1[O:53][CH2:54][O:55][CH2:56][CH:57]([C:62]([F:64])([F:65])[F:63])[C:58]([F:61])([F:60])[F:59])([N:7]([CH:8]([CH3:10])[CH3:9])[CH:11]([CH3:13])[CH3:12])[OH:6])#[N:2]

Participants

3

Reactant 2

HCID 86655994HCID 86655994, compoundHCID 178491469HCID 178491469, compound

Product 1

HCID 178491467HCID 178491467, compoundYield 86%

Procedure

This compound was synthesized in the same manner as that used for the compound 3u by using the compound 2c instead of the compound 2u. Yield was 86% (white foam).

Workup

  1. customThis compound was synthesized in the same manner as

Sources & evidence

ORD record
ord-67e8167f9c4a4748a5acc17c19d3b393
Source dataset
uspto-grants-2013_06
Patent number
US08470987B2

Reaction notes

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