HCID 136404496, compound → HCID 178491476, compound

HRID 1261866Notes

Reaction equation

HRID 1261866 reaction equation
[C:1]([CH2:3][CH2:4][PH:5]([O:14][C@@H:15]1[C@@H:19]([CH2:20][O:21][C:22]([C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=2)([C:31]2[CH:36]=[CH:35][C:34]([O:37][CH3:38])=[CH:33][CH:32]=2)[C:23]2[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][CH:24]=2)[O:18][C@@H:17]([N:45]2[CH:52]=[CH:51][C:49](=[O:50])[NH:48][C:46]2=O)[C@@H:16]1[O:53][CH2:54][O:55][CH2:56][CH:57]([C:62]([F:65])([F:64])[F:63])[C:58]([F:61])([F:60])[F:59])([N:7]([CH:11]([CH3:13])[CH3:12])[CH:8]([CH3:10])[CH3:9])[OH:6])#[N:2].[O:66]([CH2:73][C:74]([NH:76][C:77]1[NH:78]C(=O)C2N=CN(C=2[N:129]=1)[C@@H]1O[C@H](COC(C2C=CC=CC=2)(C2C=CC(OC)=CC=2)C2C=CC(OC)=CC=2)[C@@H](O)[C@H]1OCOCC(C(F)(F)F)C(F)(F)F)=[O:75])[C:67]1[CH:72]=[CH:71][CH:70]=[CH:69][CH:68]=1>>[C:1]([CH2:3][CH2:4][PH:5]([O:14][C@@H:15]1[C@@H:19]([CH2:20][O:21][C:22]([C:39]2[CH:40]=[CH:41][CH:42]=[CH:43][CH:44]=2)([C:23]2[CH:24]=[CH:25][C:26]([O:29][CH3:30])=[CH:27][CH:28]=2)[C:31]2[CH:36]=[CH:35][C:34]([O:37][CH3:38])=[CH:33][CH:32]=2)[O:18][C@@H:17]([N:45]2[C:52]3[N:129]=[C:77]([NH:76][C:74](=[O:75])[CH2:73][O:66][C:67]4[CH:68]=[CH:69][CH:70]=[CH:71][CH:72]=4)[NH:78][C:49](=[O:50])[C:51]=3[N:48]=[CH:46]2)[C@@H:16]1[O:53][CH2:54][O:55][CH2:56][CH:57]([C:62]([F:63])([F:65])[F:64])[C:58]([F:59])([F:60])[F:61])([N:7]([CH:11]([CH3:13])[CH3:12])[CH:8]([CH3:10])[CH3:9])[OH:6])#[N:2]

Participants

3

Reactant 2

HCID 136404496HCID 136404496, compoundHCID 178491469HCID 178491469, compound

Product 1

HCID 178491476HCID 178491476, compoundYield 51%

Procedure

This compound was synthesized in the same manner as that used for the compound 3u by using the compound 2g instead of the compound 2u. Yield was 51% (white foam).

Workup

  1. customThis compound was synthesized in the same manner as

Sources & evidence

ORD record
ord-9df9284e05cd46be9744c30d6df7a843
Source dataset
uspto-grants-2013_06
Patent number
US08470987B2

Reaction notes

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