Phenylboronic Acid → HCID 66710807, compound

Participants

Reaction Steps

The above compound was prepared in an analogous fashion to Example 9 replacing phenylboronic acid with N,N-dimethylsulfonamide-2-benzeneboronic acid 2-{2-[3-(2-Methoxy-ethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino]-pyrrolo[2,1-f][1,2,4]triazin-7-yl}-N,N-dimethyl-benzenesulfonamide as a yellow solid (22 mg, 18%). LCMS (E/I+) 521.20 (M+H). NMR 1H (DSMO-d6)-9.28 (s, 1H), 8.95 (s, 1H), 8.06 (d, 1H, J=7.53 Hz), 7.75-7.85 (m, 2H), 7.62 (d, 1H, J=8.57 Hz), 7.41 (s, 1H), 7.06 (d, 1H, J=8.25 Hz), 6.91 (d, 1H, J=4.60 Hz), 6.86 (d, 1H, J=4.56 Hz), 6.81 (d, 1H, J=8.09 Hz), 3.44 (t, 2H, J=5.64 Hz), 3.25 (s, 3H), 2.40-2.80 (bm, 10H), 2.32 (s, 3H).

Provenance & Evidence