Dichloromethane → HCID 86661662, compound

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Reaction Steps

Into a 1-neck round-bottom flask, [A] 4-[2-(4-Morpholin-4-yl-phenylamino)-pyrrolo[2,1-f][1,2,4]triazin-7-yl]-benzoic acid tert-butyl ester (0.34 g, 0.72 mmol), Methylene chloride (10 mL, 200 mmol) and Trifluoroacetic Acid (5.0 mL, 65 mmol) were added and stirred at room temperature overnight. The solvent was removed under vacuum. The resulting solid was washed with DCM to give 4-[2-(4-Morpholin-4-yl-phenylamino)-pyrrolo[2,1-f][1,2,4]triazin-7-yl]-benzoic acid; compound with trifluoro-acetic acid as a yellow solid. LCMS (E/I+) 416.16 (M+H). NMR 1H (DSMO-d6)-9.45 (s, 1H), 9.01 (s, 1H), 8.35 (d, 2H, J=8.40 Hz), 8.07 (d, 2H, J=8.41 Hz), 7.88 (s, 1H), 7.71 (d, 1, J=8.80 Hz), 7.30 (d 1H, J=4.76 Hz), 7.17 (d, 2H, J=8.44 Hz), 6.98 (d, 1H, J=4.80 Hz), 3.83 (t, 4H, J=4.78 Hz), 3.24 (bs, 4H).

Provenance & Evidence