反应详情

Into a Round bottom flask, 7-(4-Methanesulfonyl-phenyl)-2-methylsulfanyl-pyrrolo[2,1-f][1,2,4]triazine (0.630 g, 0.00197 mol) and Methylene chloride (50 mL, 0.8 mol) were added. m-Chloroperbenzoic acid (0.464 g, 0.00207 mol) was added portion wise. The reaction was stirred at room temperature for 30 minutes. Saturated NaHCO3 was added. The organic layer was separated, washed with Brine and dried over Na2SO4. The solid was filtered and washed with DCM. The organic was removed under vacuum. to give 2-Methanesulfinyl-7-(4-methanesulfonyl-phenyl)-pyrrolo[2,1-f][1,2,4]triazine a yellow solid (0.63 g, 93%). NMR 1H (DSMO-d6)-9.40 (s, 1H), 8.54 (d, 2H, J=8.60 Hz), 8.09 (d, 2H, J=7.56 Hz), 7.85 (d, 1H, J=4.84 Hz), 7.39 (d, 1H, J=4.88 Hz), 3.29 (s, 3H), 3.00 (s, 3H)

1. customThe organic layer was separated
2. washwashed with Brine
3. dry with materialdried over Na2SO4
4. filtrationThe solid was filtered
5. washwashed with DCM
6. customThe organic was removed under vacuum