Dichloromethane → HCID 66710941, compound

Participants

Reaction Steps

7-(5-Chloro-2-methoxy-phenyl)-2-methanesulfinyl-pyrrolo[2,1-f][1,2,4]triazine 7-(5-Chloro-2-methoxy-phenyl)-2-methylsulfanyl-pyrrolo[2,1-f][1,2,4]triazine (0.730 g, 0.00239 mol) was dissolved in Methylene chloride (20 mL, 0.4 mol) and the mixture was treated with m-Chloroperbenzoic acid (0.556 g, 0.00322 mol). The reaction was allowed to stir at room temperature until HPLC showed consumption of starting material. The reaction was partitioned between sodium thiosulfate and DCM and the combined organic layers were dried over saturated sodium sulfate. The solution was filtered and reduced. The solid was then triturated with ether to afford 700 mg of 7-(5-Chloro-2-methoxy-phenyl)-2-methanesulfinyl-pyrrolo[2,1-f][1,2,4]triazine as a yellow powder. (M+H)=322.6.

Provenance & Evidence