Diisopropylethylamine → (7-Bromo-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-(3-morpholin-4-yl-phenyl)-amine

Participants

Reaction Steps

(7-Bromo-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-(3-morpholin-4-yl-phenyl)-amine 7-Bromo-2-methanesulfinyl-pyrrolo[2,1-f][1,2,4]triazine (2.00 g, 0.00769 mol), 3-Morpholin-4-yl-phenylamine (1.37 g, 0.00769 mol) and N,N-Diisopropylethylamine (1.49 g, 0.0115 mol) were dissolved in 2-Methoxyethanol (13.7 mL). The reaction was microwaved on 300 watts, 180° C. for 80 minutes. The solvent was then removed en vacuo. The crude mixture was purified by Isco flash column chromatography (Hexane/Ethyl Acetate). Combined fractions were reduced en vacuo to afford 1.40 g of (7-Bromo-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-(3-morpholin-4-yl-phenyl)-amine as a brown solid. (M+H)=376.05.

Provenance & Evidence