1-(4-Nitrophenyl)piperazine → HCID 66711177, compound

Participants

Reaction Steps

The compound was prepared in an analogous fashion to Example 69 replacing 1-(4-Nitro-phenyl)-piperazine with 1-(3-Nitro-phenyl)-piperazine and 2-Methanesulfinyl-7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazine with 7-(5-Chloro-2-methoxy-phenyl)-2-methanesulfinyl-pyrrolo[2,1-f][1,2,4]triazine to afford 25.13 mg of (S)-1-(4-{3-[7-(5-Chloro-2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-ylamino]-phenyl}-piperazin-1-yl)-propan-2-ol as a lyophilized powder. (M+H)=493.11. 1H NMR (400 MHz, DMSO, d6) δ 9.34 (s, 1H), 8.98 (s, 1H), 7.94 (m, 1H), 7.50 (dd, 1H, J=2.68, 6.20 Hz), 7.39 (d, 1H, J=8.20 Hz), 7.23 (d, 1H, J=8.96 Hz), 7.14 (m, 2H), 7.01 (d, 1H, J=4.68 Hz), 6.93 (d, 1H, J=4.64 Hz), 6.59 (dd, 1H, J=1.80, 6.32 Hz), 4.11 (m, 2H), 3.80 (s, 3H), 3.73 (m, 4H), 3.16 (m, 3H), 3.02 (m, 2H), 1.15 (d, 3H, J=6.16 Hz).

Provenance & Evidence