1-(4-Nitrophenyl)piperazine → HCID 66711040, compound

Participants

Reaction Steps

The compound was prepared in an analogous fashion to Example 73 replacing 1-(4-Nitro-phenyl)-piperazine with 1-(3-Nitro-phenyl)-piperazine and 2-Methanesulfinyl-7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazine with 7-(5-Chloro-2-methoxy-phenyl)-2-methanesulfinyl-pyrrolo[2,1-f][1,2,4]triazine to afford 19.24 mg of (R)-1-(4-{3-[7-(5-Chloro-2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-ylamino]-phenyl}-piperazin-1-yl)-propan-2-ol as a lyophilized powder. (M+H)=493.09. 1H NMR (400 MHz, DMSO, d6) δ 9.34 (s, 1H), 8.98 (s, 1H), 7.94 (m, 1H), 7.50 (dd, 1H, J=2.64, 6.24 Hz), 7.39 (d, 1H, J=8.12 Hz), 7.24 (d, 1H, J=8.96 Hz), 7.14 (m, 2H), 7.01 (d, 1H, J=4.68 Hz), 6.93 (d, 1H, J=4.68 Hz), 6.59 (dd, 1H, J=1.80, 6.48 Hz), 4.12 (m, 2H), 3.80 (s, 3H), 3.53 (m, 4H), 3.15 (m, 3H), 3.02 (m, 2H), 1.15 (d, 2H, J=6.16 Hz).

Provenance & Evidence