1-(4-Nitrophenyl)piperazine → HCID 66711038, compound

Participants

Reaction Steps

The compound was prepared in an analogous fashion to Example 73 replacing 1-(4-Nitro-phenyl)-piperazine with 1-(3-Nitro-phenyl)-piperazine and 2-Methanesulfinyl-7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazine with 7-(3-Chloro-phenyl)-2-methanesulfinyl-pyrrolo[2,1-f][1,2,4]triazine to afford 22.28 mg of (R)-1-(4-{3-[7-(3-Chloro-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-ylamino]-phenyl}-piperazin-1-yl)-propan-2-ol as a lyophilized powder. (M+H)=463.12. 1H NMR (400 MHz, DMSO, d6) δ 9.52 (m, 1H), 9.41 (s, 1H), 8.39 (m, 1H), 8.06 (d, 1H, J=7.68 Hz), 7.50 (m, 3H), 7.25 (m, 2H), 7.18 (m, 1H), 6.97 (d, 1H, J=4.76 Hz), 6.67 (d, 1H, J=8.00 Hz), 4.11 (m, 2H), 3.66 (m, 2H), 3.53 (m, 2H), 3.14 (m, 3H), 3.03 (m, 2H), 1.15 (d, 3H, J=6.16 Hz).

Provenance & Evidence