Hydrochloric Acid → 2-Methyl-1-[4-(3-nitro-phenyl)-piperazin-1-yl]-propan-2-ol

Participants

Reaction Steps

2-Methyl-1-[4-(3-nitro-phenyl)-piperazin-1-yl]-propan-2-ol 1-(3-Nitro-phenyl)-piperazine; hydrochloride (2.0 g, 0.0082 mol) was dissolved in Methanol (42.5 mL) and the reaction mixture was placed in a sealed tube. 1,2-epoxy-2-methylpropane (0.888 g, 0.0123 mol) was then added at room temperature and the reaction was allowed to stir overnight. The mixture was then reduced en vacuo and the product was isolated by Isco flash column chromatography (DCM/MeOH) to afford 1.60 grams of 2-Methyl-1-[4-(3-nitro-phenyl)-piperazin-1-yl]-propan-2-ol as a yellow powder.

Provenance & Evidence