Acetic Acid → HCID 66710911, compound

Participants

Reaction Steps

A solution of 4-[1-(3-methoxy-4-nitro-phenyl)-piperidin-3-yl]-piperazine-1-carboxylic acid benzyl ester (300 mg, 0.66 mmol) in 4 M of hydrogen bromide in acetic acid (6 mL, 20 mmol) was heated at 40-45° C. for 45 min, then allowed to cool to room temperature while being stirred overnight. The orange homogenous solution was added dropwise to a vigorously stirred flask of EtOAc (50 mL) and the resulting precipitate was filtered, washed with EtOAc and dried in-vacuo to give 294 mg of an orange solid, used without further purification. MS=322 (M-HBr+1).

Provenance & Evidence