Diisopropylethylamine → HCID 66711116, compound

Participants

Reaction Steps

A mixture of 1-{4-[1-(4-amino-3-methoxy-phenyl)-piperidin-3-yl]-piperazin-1-yl}-ethanone (80 mg, 0.24 mmol) and 2-methanesulfinyl-7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazine (46 mg, 0.16 mmol) in 2-methoxyethanol (0.50 mL) and treated with N,N-Diisopropylethylamine (56 μL, 0.32 mmol). The reaction was microwaved on 300 watts, 200 C for 9.5 hours. The sample was diluted with methanol (10 mL), filtered and concentrated. The crude product was purified by RF-HPLC to afford 34 mg of the title compound as an amber powder after lyophyllization. MS=556 (M-TFA+1); NMR (DMSO-d6, ppm): 9.83 (br, 1H), 8.91 (s, 1H), 7.86 (m, 2H), 7.56 (s, 1H), 7.45 (t, J=7 Hz, 1H), 7.20 (d, J=7 Hz, 1H), 7.10 (t, J=7 Hz, 1H), 6.95 (q, J=5 Hz, 14 Hz, 2H), 6.69 (s, 1H), 6.46 (d, J=7 Hz, 1H), 3.87 (s, 3H), 3.80 (s, 3H), 3.50 (m, 4H), 2.91 (t, J=12 Hz, 2H), 2.70 (t, J=10 Hz, 2H), 2.33 (m, 1H), 2.13 (m, 2H), 2.07 (s, 3H), 1.89 (m, 1H), 1.64 (t, J=10 Hz, 2H).

Provenance & Evidence