2-Methanesulfinyl-7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazine → HCID 66711767, compound

HRID 1261986Notes

Reaction equation

HRID 1261986 reaction equation
CS([C:4]1[N:9]=[CH:8][C:7]2=CC=[C:12]([C:13]3[CH:18]=CC=CC=3OC)[N:6]2[N:5]=1)=O.CS([C:24]1[N:29]=[CH:28][C:27]2=[CH:30][CH:31]=[C:32]([C:33]3[CH:34]=[N:35][CH:36]=[CH:37][CH:38]=3)[N:26]2[N:25]=1)=O>>[N:35]1[CH:36]=[CH:37][CH:38]=[C:33]([C:32]2[N:26]3[C:27]([CH:28]=[N:29][C:24]([N:5]4[C:18]5[CH:13]=[CH:12][N:6]=[CH:7][C:8]=5[N:9]=[CH:4]4)=[N:25]3)=[CH:30][CH:31]=2)[CH:34]=1

Participants

3

Reactant 2

HCID 667107912-Methanesulfinyl-7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazineHCID 667112752-Methanesulfinyl-7-pyridin-3-yl-pyrrolo[2,1-f][1,2,4]triazine

Product 1

HCID 66711767HCID 66711767, compound

Procedure

The compound was made in an analogous fashion to Example 322 replacing 2-Methanesulfinyl-7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazine with 2-Methanesulfinyl-7-pyridin-3-yl-pyrrolo[2,1-f][1,2,4]triazine to afford 60.57 mg of 1-(7-Pyridin-3-yl-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-1H-imidazo[4,5-c]pyridine as a lyophilized powder. (M+H)=314.6. 1H NMR (400 MHz, DMSO, d6) δ 9.43 (s, 1H), 9.36 (s, 1H), 9.29 (s, 1H), 8.69 (m, 2H), 8.50 (m, 2H), 8.23 (m, 1H), 7.65 (m, 2H), 7.38 (d, 1H, J=4.84 Hz).

Sources & evidence

ORD record
ord-021a73d88fd64dde8bf259c27633305c
Source dataset
uspto-grants-2013_06
Patent number
US08471005B2

Reaction notes

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