2-Methanesulfinyl-7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazine → HCID 66710845, compound

HRID 1261990Notes

Reaction equation

HRID 1261990 reaction equation
CS([C:4]1[N:9]=[CH:8][C:7]2=CC=[C:12]([C:13]3[CH:18]=CC=CC=3OC)[N:6]2[N:5]=1)=O.CS([C:24]1[N:29]=[CH:28][C:27]2=[CH:30][CH:31]=[C:32]([C:33]3[CH:38]=[CH:37][C:36]([S:39]([CH3:42])(=[O:41])=[O:40])=[CH:35][CH:34]=3)[N:26]2[N:25]=1)=O>>[CH3:42][S:39]([C:36]1[CH:37]=[CH:38][C:33]([C:32]2[N:26]3[C:27]([CH:28]=[N:29][C:24]([N:5]4[C:18]5[CH:13]=[CH:12][N:6]=[CH:7][C:8]=5[N:9]=[CH:4]4)=[N:25]3)=[CH:30][CH:31]=2)=[CH:34][CH:35]=1)(=[O:41])=[O:40]

Participants

3

Reactant 2

HCID 667107912-Methanesulfinyl-7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazineHCID 667110462-(Methylsulfinyl)-7-(4-(methylsulfonyl)phenyl)pyrrolo[2,1-f][1,2,4]triazine

Product 1

HCID 66710845HCID 66710845, compound

Procedure

The compound was made in an analogous fashion to Example 322 replacing 2-Methanesulfinyl-7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazine with 2-Methanesulfinyl-7-(4-methanesulfonyl-phenyl)-pyrrolo[2,1-f][1,2,4]triazine to afford 16.33 mg of 1-[7-(4-Methanesulfonyl-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-yl]-1H-imidazo[4,5-c]pyridine as a lyophilized powder. (M+H)=391.6. 1H NMR (400 MHz, DMSO, d6) δ 9.53 (m, 3H), 8.81 (m, 1H), 8.62 (d, 1H, J=6.32 Hz), 8.54 (m, 2H), 8.18 (m, 2H), 7.81 (d, 1H, J=4.92 Hz), 7.46 (d, 1H, J=4.93 Hz), 2.50 (s, 3H).

Sources & evidence

ORD record
ord-289a79611fa0408ea7b1001fa37192c5
Source dataset
uspto-grants-2013_06
Patent number
US08471005B2

Reaction notes

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