1-Methoxy-2-propanol → HCID 66710953, compound

Participants

Reaction Steps

2-Methanesulfinyl-7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazine (100.0 mg, 0.0003480 mol), N,N-Diisopropylethylamine (0.0909 mL, 0.000522 mol) and 4-[3-(4-Methyl-piperazin-1-yl)-piperidin-1-yl]-phenylamine (0.191 g, 0.000696 mol) were dissolved in 1-Methoxy-2-propanol (0.99 mL, 0.010 mol) and the reaction was irradiated at 300 watts, 180° C. for 40 minutes or until HPLC showed consumption of starting material. The reaction mixture was then reduced en vacuo and the product was isolated and purified by Gilson prep HPLC to afford 78.00 mg of [7-(2-Methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-yl]-{4-[3-(4-methyl-piperazin-1-yl)-piperidin-1-yl]-phenyl}-amine as a lyophilized powder. (M+H)=498.3. 1H NMR (400 MHz, DMSO, d6) δ 9.37 (s, 1H), 8.93 (s, 1H), 7.81 (dd, 1H, J=1.62, 5.96 Hz), 7.67 (d, 2H, J=8.56 Hz), 7.45 (m, 1H), 7.21 (d, 1H, J=8.05 Hz), 7.11 (m, 3H), 6.92 (m, 2H), 3.92 (m, 4H), 3.79 (s, 3H), 3.62 (m, 2H), 3.45 (m, 3H), 3.31 (m, 2H), 3.13 (m, 2H), 2.79 (m, 3H), 1.99 (m, 1H), 1.88 (m, 1H), 1.67 (m, 1H), 1.51 (m, 1H).

Provenance & Evidence