1-Methoxy-2-propanol → HCID 66711031, compound

Participants

Reaction Steps

2-Methanesulfinyl-7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazine (125.0 mg, 0.0004350 mol), N,N-Diisopropylethylamine (0.3789 mL, 0.002175 mol) and 4-(4-Methyl-piperazin-1-ylmethyl)-phenylamine (0.179 g, 0.000870 mol) were dissolved in 1-Methoxy-2-propanol (0.500 mL, 0.00512 mol) and the reaction was irradiated at 300 watts, 180° C. for 40 minutes or until HPLC showed consumption of starting material. The reaction mixture was then reduced en vacuo and the product was isolated and purified by Gilson prep HPLC to afford 46.12 mg of [7-(2-Methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-yl]-[4-(4-methyl-piperazin-1-ylmethyl)-phenyl]-amine as a lyophilized powder. (M+H)=429.07. 1H NMR (400 MHz, DMSO, d6) δ 9.55 (s, 1H), 8.97 (s, 1H), 7.79 (dd, 1H, J=1.64, 5.97 Hz), 7.73 (d, 2H, J=8.36 Hz), 7.48 (m, 1H), 7.22 (d, 3H, J=7.96 Hz), 7.12 (t, 1H, J=7.45 Hz), 6.95 (m, 2H), 3.85 (s, 3H), 3.72 (m, 6H), 3.40 (m, 4H), 2.76 (s, 3H).

Provenance & Evidence