1-Methoxy-2-propanol → HCID 66711002, compound

Participants

Reaction Steps

(2-Methanesulfinyl-pyrrolo[2,1-f][1,2,4]triazin-7-ylmethyl)-phenyl-amine (40.0 mg, 0.140 mmol), 4-(4-morpholino)aniline (49.8 mg, 0.279 mmol) and N,N-Diisopropylethylamine (0.0730 mL, 0.419 mmol) were dissolved in 1-Methoxy-2-propanol (0.50 mL, 5.1 mmol) and the reaction was irradiated at 300 watts, 200° C. for 20 minutes or longer depending on HPLC monitoring. The reaction was then reduced under nitrogen. The crude reaction mixture was purified via Gilson reverse phase chromatography. Combined fractions were lyophilized to afford 17.12 mg of (4-Morpholin-4-yl-phenyl)-(7-phenylaminomethyl-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-amine as a TFA salt. (M+H)=401.16. 1H NMR (400 MHz, DMSO, d6) δ 9.32 (s, 1H), 8.87 (s, 1H), 7.72 (d, 2H, J=8.29 Hz), 7.09 (t, 2H, J=7.32 Hz), 6.97 (m, 2H), 6.76 (m, 1H), 6.67 (m, 3H), 6.60 (t, 1H, J=7.32 Hz), 4.59 (s, 2H), 3.77 (m, 4H), 3.12 (m, 4H).

Provenance & Evidence