反应详情

(4-Methyl-piperazin-1-yl)-[1-(4-nitro-phenyl)-piperidin-4-yl]-methanone was prepared in a similar manner as (4-Methyl-piperazin-1-yl)-[1-(4-nitro-phenyl)-piperidin-3-yl]-methanone of Example 443a after substituting 1-(4-Nitro-phenyl)-piperidine-4-carboxylic acid for 1-(4-Nitro-phenyl)-piperidine-3-carboxylic acid. (4-Methyl-piperazin-1-yl)-[1-(4-nitro-phenyl)-piperidin-3-yl]-methanone was isolated as a yellow solid from water (570 mg, 86%). LC: 100%; LC/MS (E/I+) 333.13 (M+H).