HCID 66711060, compound → HCID 66711823, compound

HRID 1262046Notes

Reaction equation

HRID 1262046 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][CH2:11][C@H:10]([C:14]([N:16]3[CH2:21][CH2:20][N:19]([CH3:22])[CH2:18][CH2:17]3)=[O:15])[CH2:9]2)=[CH:4][C:3]=1[O:23][CH3:24].COC1C=C(N2CCC[C@@H](C(N3CCN(C)CC3)=O)C2)C=CC=1[N+]([O-])=O>>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][CH2:11][C@@H:10]([C:14]([N:16]3[CH2:17][CH2:18][N:19]([CH3:22])[CH2:20][CH2:21]3)=[O:15])[CH2:9]2)=[CH:4][C:3]=1[O:23][CH3:24]

Participants

3

Reactant 2

HCID 66711060HCID 66711060, compoundHCID 66711468HCID 66711468, compound

Product 1

HCID 66711823HCID 66711823, compound

Procedure

[(R)-1-(4-Amino-3-methoxy-phenyl)-piperidin-3-yl]-(4-methyl-piperazin-1-yl)-methanone was prepared in an analogous fashion to [(S)-1-(4-Amino-3-methoxy-phenyl)-piperidin-3-yl]-(4-methyl-piperazin-1-yl)-methanone of Example 460c replacing [(S)-1-(3-Methoxy-4-nitro-phenyl)-piperidin-3-yl]-(4-methyl-piperazin-1-yl)-methanone with [(R)-1-(3-Methoxy-4-nitro-phenyl)-piperidin-3-yl]-(4-methyl-piperazin-1-yl)-methanone. (390 mg, 98%). LC/MS (E/I+) 333.20 (M+H).

Sources & evidence

ORD record
ord-803e95c9484445dd9a8ad4ff56651bab
Source dataset
uspto-grants-2013_06
Patent number
US08471005B2

Reaction notes

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