HCID 66711468, compound → HCID 66710961, compound

HRID 1262048Notes

Reaction equation

HRID 1262048 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][CH2:11][C@H:10]([C:14]([N:16]3[CH2:21][CH2:20][N:19]([CH3:22])[CH2:18][CH2:17]3)=O)[CH2:9]2)=[CH:4][C:3]=1[O:23][CH3:24].COC1C=C(N2CCC[C@H](CN3CCN(C)CC3)C2)C=CC=1[N+]([O-])=O>>[CH3:24][O:23][C:3]1[CH:4]=[C:5]([N:8]2[CH2:13][CH2:12][CH2:11][C@H:10]([CH2:14][N:16]3[CH2:17][CH2:18][N:19]([CH3:22])[CH2:20][CH2:21]3)[CH2:9]2)[CH:6]=[CH:7][C:2]=1[NH2:1]

Participants

3

Reactant 2

HCID 66711468HCID 66711468, compoundHCID 66711627HCID 66711627, compound

Product 1

HCID 66710961HCID 66710961, compound

Procedure

2-Methoxy-4-[(R)-3-(4-methyl-piperazin-1-ylmethyl)-piperidin-1-yl]-phenylamine was prepared in an analogous fashion to [(S)-1-(4-Amino-3-methoxy-phenyl)-piperidin-3-yl]-(4-methyl-piperazin-1-yl)-methanone of Example 460c replacing [(S)-1-(3-Methoxy-4-nitro-phenyl)-piperidin-3-yl]-(4-methyl-piperazin-1-yl)-methanone with 1-[(R)-1-(3-Methoxy-4-nitro-phenyl)-piperidin-3-ylmethyl]-4-methyl-piperazine. (160 mg, 100%). LC/MS (E/I+) 319.22 (M+H).

Sources & evidence

ORD record
ord-27a16df686c744dab9f1be79d21dcec5
Source dataset
uspto-grants-2013_06
Patent number
US08471005B2

Reaction notes

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