HCID 66710854, compound → HCID 66649717, compound

HRID 1262049Notes

Reaction equation

HRID 1262049 reaction equation
NC1C=CC(N2CCC[C@H](C(N3CCN(C)CC3)=O)C2)=CC=1OC.[CH3:25][O:26][C:27]1[CH:28]=[C:29]([N:36]2[CH2:41][CH2:40][CH:39]([CH2:42][N:43]3[CH2:48][CH2:47][N:46]([CH3:49])[CH2:45][CH2:44]3)[CH2:38][CH2:37]2)[CH:30]=[CH:31][C:32]=1[N+:33]([O-])=O>>[CH3:25][O:26][C:27]1[CH:28]=[C:29]([N:36]2[CH2:41][CH2:40][CH:39]([CH2:42][N:43]3[CH2:44][CH2:45][N:46]([CH3:49])[CH2:47][CH2:48]3)[CH2:38][CH2:37]2)[CH:30]=[CH:31][C:32]=1[NH2:33]

Participants

3

Reactant 2

HCID 66710854HCID 66710854, compoundHCID 66711468HCID 66711468, compound

Product 1

HCID 66649717HCID 66649717, compound

Procedure

2-Methoxy-4-[4-(4-methyl-piperazin-1-ylmethyl)-piperidin-1-yl]-phenylamine was prepared in an analogous fashion to [(S)-1-(4-Amino-3-methoxy-phenyl)-piperidin-3-yl]-(4-methyl-piperazin-1-yl)-methanone of Example 460c replacing [(S)-1-(3-Methoxy-4-nitro-phenyl)-piperidin-3-yl]-(4-methyl-piperazin-1-yl)-methanone with 1-[1-(3-Methoxy-4-nitro-phenyl)-piperidin-4-ylmethyl]-4-methyl-piperazine. (200 mg, 100%). LC/MS (E/I+) 319.16 (M+H).

Sources & evidence

ORD record
ord-50d97d0e9ebf4fa58aa7e4d0b80cebe5
Source dataset
uspto-grants-2013_06
Patent number
US08471005B2

Reaction notes

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