反应详情

2-Methoxy-4-[4-(4-methyl-piperazin-1-ylmethyl)-piperidin-1-yl]-phenylamine was prepared in an analogous fashion to [(S)-1-(4-Amino-3-methoxy-phenyl)-piperidin-3-yl]-(4-methyl-piperazin-1-yl)-methanone of Example 460c replacing [(S)-1-(3-Methoxy-4-nitro-phenyl)-piperidin-3-yl]-(4-methyl-piperazin-1-yl)-methanone with 1-[1-(3-Methoxy-4-nitro-phenyl)-piperidin-4-ylmethyl]-4-methyl-piperazine. (200 mg, 100%). LC/MS (E/I+) 319.16 (M+H).