反应详情

N-(4-Amino-3-methoxy-phenyl)-N-methyl-2-(4-methyl-piperazin-1-yl)-acetamide was prepared in an analogous fashion to [(S)-1-(4-Amino-3-methoxy-phenyl)-piperidin-3-yl]-(4-methyl-piperazin-1-yl)-methanone of Example 460c replacing [(S)-1-(3-Methoxy-4-nitro-phenyl)-piperidin-3-yl]-(4-methyl-piperazin-1-yl)-methanone with N-(3-Methoxy-4-nitro-phenyl)-N-methyl-2-(4-methyl-piperazin-1-yl)-acetamide. N-(4-Amino-3-methoxy-phenyl)-N-methyl-2-(4-methyl-piperazin-1-yl)-acetamide was purified by trituration with Et2O to give pure product as a brown solid, MP 115-118° C. (390 mg, 93%). LC/MS (E/I+) 293 (M−15).

1. customN-(4-Amino-3-methoxy-phenyl)-N-methyl-2-(4-methyl-piperazin-1-yl)-acetamide was purified by trituration with Et2O
2. customto give pure product as a brown solid, MP 115-118° C. (390 mg, 93%)