(R)-3-Pyrrolidinol → HCID 66711057, compound

HRID 1262056Notes

Reaction equation

HRID 1262056 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:12]2[CH2:17][CH2:16][CH:15]([N:18]([CH3:20])[CH3:19])[CH2:14][CH2:13]2)[CH:6]=[CH:7][C:8]=1[N+:9]([O-:11])=[O:10].N1CC[C@@H:23]([OH:26])[CH2:22]1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:12]2[CH2:17][CH2:16][CH:15]([N:18]3[CH2:19][CH2:22][C@@H:23]([OH:26])[CH2:20]3)[CH2:14][CH2:13]2)[CH:6]=[CH:7][C:8]=1[N+:9]([O-:11])=[O:10]

Participants

3

Reactant 2

HCID 2759337(R)-3-PyrrolidinolHCID 574161521-(3-methoxy-4-nitrophenyl)-N,N-dimethylpiperidin-4-amine

Product 1

HCID 66711057HCID 66711057, compound

Procedure

(R)-1-[1-(3-Methoxy-4-nitro-phenyl)-piperidin-4-yl]-pyrrolidin-3-ol was prepared in an analogous fashion to [1-(3-Methoxy-4-nitro-phenyl)-piperidine-4-yl]dimethyl-amine of Example 475a replacing Dimethylamine with (R)-Pyrrolidin-3-ol. The crude material was purified via trituration with Et2O to yield a yellow solid, MP 137-139° C. (248 mg, 64%). LC/MS (E/I+) 322.16 (M+H).

Workup

  1. customThe crude material was purified via trituration with Et2O
  2. customto yield a yellow solid, MP 137-139° C. (248 mg, 64%)

Sources & evidence

ORD record
ord-4c923d007c1c44dbb9560cb79f0d555b
Source dataset
uspto-grants-2013_06
Patent number
US08471005B2

Reaction notes

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