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HRID1262056

反应详情

EQUATION

反应方程式

HRID 1262056 的结构方程式

REACTANTS

反应物

2
结构：O[C@@H]1CCNC1
HCID2759337

(R)-3-Hydroxypyrrolidine

C4H9NO

结构：COc1cc(N2CCC(N(C)C)CC2)ccc1[N+](=O)[O-]
HCID57416152

1-(3-Methoxy-4-nitrophenyl)-N,N-dimethylpiperidin-4-amine

C14H21N3O3

PRODUCTS

生成物

1
结构：COc1cc(N2CCC(N3CC[C@@H](O)C3)CC2)ccc1[N+](=O)[O-]
HCID66711057

未命名化合物

PROCEDURE

实验过程

(R)-1-[1-(3-Methoxy-4-nitro-phenyl)-piperidin-4-yl]-pyrrolidin-3-ol was prepared in an analogous fashion to [1-(3-Methoxy-4-nitro-phenyl)-piperidine-4-yl]dimethyl-amine of Example 475a replacing Dimethylamine with (R)-Pyrrolidin-3-ol. The crude material was purified via trituration with Et2O to yield a yellow solid, MP 137-139° C. (248 mg, 64%). LC/MS (E/I+) 322.16 (M+H).

WORKUP

后处理

  1. customThe crude material was purified via trituration with Et2O
  2. customto yield a yellow solid, MP 137-139° C. (248 mg, 64%)