8-(3-Methoxy-4-nitrophenyl)-1,4-dioxa-8-azaspiro[4.5]decane → 4-(1,4-Dioxa-8-azaspiro[4.5]decan-8-yl)-2-methoxyaniline

Participants

Reaction Steps

4-(1,4-Dioxa-8-aza-spiro[4.5]dec-8-yl)-2-methoxy-phenylamine was prepared in an analogous fashion to [(S)-1-(4-Amino-3-methoxy-phenyl)-piperidin-3-yl]-(4-methyl-piperazin-1-yl)-methanone of Example 460c replacing [(S)-1-(3-Methoxy-4-nitro-phenyl)-piperidin-3-yl]-(4-methyl-piperazin-1-yl)-methanone with 8-(3-Methoxy-4-nitro-phenyl)-1,4-dioxa-8-aza-spiro[4.5]decane (1.25 g, 93%). LC/MS (E/I+) 265.08 (M+H).

Provenance & Evidence