HCID 66710908, compound → HCID 66711309, compound

HRID 1262062Notes

Reaction equation

HRID 1262062 reaction equation
NC1C=CC(N2CCC[C@H](C(N3CCN(C)CC3)=O)C2)=CC=1OC.[CH3:25][O:26][C:27]1[CH:28]=[C:29]([N:36]2[CH2:41][CH2:40][CH:39]([N:42]3[CH2:46][CH2:45][C@H:44]([OH:47])[CH2:43]3)[CH2:38][CH2:37]2)[CH:30]=[CH:31][C:32]=1[N+:33]([O-])=O>>[NH2:33][C:32]1[CH:31]=[CH:30][C:29]([N:36]2[CH2:41][CH2:40][CH:39]([N:42]3[CH2:46][CH2:45][C@H:44]([OH:47])[CH2:43]3)[CH2:38][CH2:37]2)=[CH:28][C:27]=1[O:26][CH3:25]

Participants

3

Reactant 2

HCID 66710908HCID 66710908, compoundHCID 66711468HCID 66711468, compound

Product 1

HCID 66711309HCID 66711309, compound

Procedure

(S)-1-[1-(4-Amino-3-methoxy-phenyl)-piperidin-4-yl]-pyrrolidin-3-ol was prepared in an analogous fashion to [(S)-1-(4-Amino-3-methoxy-phenyl)-piperidin-3-yl]-(4-methyl-piperazin-1-yl)-methanone of Example 460c replacing [(S)-1-(3-Methoxy-4-nitro-phenyl)-piperidin-3-yl]-(4-methyl-piperazin-1-yl)-methanone with (S)-1-[1-(3-Methoxy-4-nitro-phenyl)-piperidin-4-yl]-pyrrolidin-3-ol (150 mg, 99%). LC/MS (E/I+) 292.15 (M+H).

Sources & evidence

ORD record
ord-2eaa4cb437674e1e9f78a1373ffd89bd
Source dataset
uspto-grants-2013_06
Patent number
US08471005B2

Reaction notes

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