HCID 66711403, compound → HCID 66712036, compound

HRID 1262069Notes

Reaction equation

HRID 1262069 reaction equation
NC1C=CC(N2CCC[C@H](C(N3CCN(C)CC3)=O)C2)=CC=1OC.[CH3:25][N:26]1[CH2:31][CH2:30][N:29]([C:32]([N:34]2[CH2:39][CH2:38][CH:37]([C:40]3[CH:45]=[CH:44][C:43]([N+:46]([O-])=O)=[CH:42][CH:41]=3)[CH2:36][CH2:35]2)=[O:33])[CH2:28][CH2:27]1>>[NH2:46][C:43]1[CH:44]=[CH:45][C:40]([CH:37]2[CH2:38][CH2:39][N:34]([C:32]([N:29]3[CH2:30][CH2:31][N:26]([CH3:25])[CH2:27][CH2:28]3)=[O:33])[CH2:35][CH2:36]2)=[CH:41][CH:42]=1

Participants

3

Reactant 2

HCID 66711403HCID 66711403, compoundHCID 66711468HCID 66711468, compound

Product 1

HCID 66712036HCID 66712036, compound

Procedure

[4-(4-Amino-phenyl)-piperidin-1-yl]-(4-methyl-piperazin-1-yl)-methanone was prepared in an analogous fashion to [(S)-1-(4-Amino-3-methoxy-phenyl)-piperidin-3-yl]-(4-methyl-piperazin-1-yl)-methanone of Example 460c replacing [(S)-1-(3-Methoxy-4-nitro-phenyl)-piperidin-3-yl]-(4-methyl-piperazin-1-yl)-methanone with (4-Methyl-piperazin-1-yl)-[4-(4-nitro-phenyl)-piperidin-1-yl]-methanone.

Sources & evidence

ORD record
ord-e374f29a9f9d4c8a9aa1cd88c0c2529e
Source dataset
uspto-grants-2013_06
Patent number
US08471005B2

Reaction notes

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