HRID1262073

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CS(=O)c1ncc2ccc(-c3ccccc3NS(C)(=O)=O)n2n1

HCID66711409

未命名化合物

结构：Cc1cc2cnc(S(C)=O)nn2c1-c1ccccc1NS(C)(=O)=O

HCID66712338

未命名化合物

PRODUCTS

生成物

结构：Cc1cc2cnc(S(C)=O)nn2c1-c1ccccc1N(C)S(C)(=O)=O

HCID66711971

未命名化合物

HCID66712338

未命名化合物

PROCEDURE

实验过程

N-[2-(2-Methanesulfinyl-6-methyl-pyrrolo[2,1-f][1,2,4]triazin-7-yl)-phenyl]-N-methyl-methanesulfonamide was prepared in an analogous fashion to Example 1220 replacing N-[2-(2-methylsulfinyl-pyrrolo[2,1-f][1,2,4]triazin-7-yl)-phenyl]-methanesulfonamide with N-[2-(6-Methyl-2-methylsulfinyl-pyrrolo[2,1-f][1,2,4]triazin-7-yl)-phenyl]-methanesulfonamide to give N-[2-(6-Methyl-2-methylsulfinyl-pyrrolo[2,1-f][1,2,4]triazin-7-yl)-phenyl]-methanesulfonamide as an orange residue, which was used without further manipulation (0.13 g, 96%). LC/MS (E/I+) 379.05 (M+H).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6b28a840c96641e3b1c4d55fc931d87a
来源数据集: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08471005B2
来源说明: uspto-grants-2013_06

反应 SMILES

[CH3:1][S:2]([C:4]1[N:9]=[CH:8][C:7]2=[CH:10][CH:11]=[C:12]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[NH:19][S:20]([CH3:23])(=[O:22])=[O:21])[N:6]2[N:5]=1)=[O:3].[CH3:24][C:25]1[CH:26]=[C:27]2[N:32]([C:33]=1[C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][C:35]=1[NH:40][S:41]([CH3:44])(=[O:43])=[O:42])[N:31]=[C:30]([S:45]([CH3:47])=[O:46])[N:29]=[CH:28]2>>[CH3:47][S:45]([C:30]1[N:29]=[CH:28][C:27]2=[CH:26][C:25]([CH3:24])=[C:33]([C:34]3[CH:39]=[CH:38][CH:37]=[CH:36][C:35]=3[N:40]([CH3:1])[S:41]([CH3:44])(=[O:42])=[O:43])[N:32]2[N:31]=1)=[O:46].[CH3:24][C:11]1[CH:10]=[C:7]2[N:6]([C:12]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[NH:19][S:20]([CH3:23])(=[O:22])=[O:21])[N:5]=[C:4]([S:2]([CH3:1])=[O:3])[N:9]=[CH:8]2