Hydrochloric Acid → [7-(2-Methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-yl]-(2-methyl-benzoxazol-5-yl)-amine

Participants

Reaction Steps

The Title compound was prepared in the following manner: A mixture of Trifluoro-methanesulfonic acid 7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-yl ester (100 mg, 0.3 mmol), 2-Methyl-benzoxazol-5-ylamine; hydrochloride (100 mg, 0.5 mmol), N,N-Diisopropylethylamine (2 mL, 10 mmol), and 1-Methoxy-2-propanol (0.3 mL, 3 mmol) were heated at 80° C. overnight. The reaction was concentrated, filtered and placed onto the Gilson. The pure fractions were lyophilized to give a yellow solid (30 mg, 20%). LCMS (E/I+) 372 (M+H). NMR 1H (DMSO-d6)-9.5 (s, 1H), 9.0 (s, 1H), 8.2 (s, 1H), 7.78 (d, 1H, J=7.80 Hz), 7.45-7.54 (m, 3H), 7.23 (d, 1H, J=8.26), 7.12 (t, 1H, J=7.51 Hz), 6.92-6.96 (m, 2H), 3.84 (s, 3H), 2.58 (s, 3H).

Provenance & Evidence