7-amino-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-3-one → 7-[7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-ylamino]-4-methyl-4H-benzo[1,4]oxazin-3-one

Participants

Reaction Steps

The titled compound was prepared in analogous fashion as Example 113 using 2-methanesulfinyl-7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazine and 7-amino-4-methyl-4H-benzo[1,4]oxazin-3-one to give 7-[7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-ylamino]-4-methyl-4H-benzo[1,4]oxazin-3-one as a pale yellow foam. LCMS (E/I+) 402 (M+H). 1H NMR (400 MHz, CDCl3) δ 8.69 (s, 1H), 7.75 (dd, 1H, J=1.5, 7.5 Hz), 7.64 (s, 1H), 7.41 (td, 1H, J=2, 8.2 Hz), 7.05 (m, 2H), 6.94 (d, 1H, J=4.6 Hz), 6.86 (m, 4H), 4.55 (s, 2H), 2.79 (s, 3H), 2.89 (s, 3H).

Provenance & Evidence