7-amino-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-3-one → 4-methyl-7-(7-pyridin-3-yl-pyrrolo[2,1-f][1,2,4]triazin-2-ylamino)-4H-benzo[1,4]oxazin-3-one

Participants

Reaction Steps

The titled compound was prepared in analogous fashion as Example 113 using 2-methanesulfinyl-7-pyridin-3-yl-pyrrolo[2,1-f][1,2,4]triazine and 7-amino-4-methyl-4H-benzo[1,4]oxazin-3-one to give 4-methyl-7-(7-pyridin-3-yl-pyrrolo[2,1-f][1,2,4]triazin-2-ylamino)-4H-benzo[1,4]oxazin-3-one as a yellow lyophilate (29.4, 13.3% yield). LCMS (E/I+) 373 (M+H). 1H NMR (400 MHz, CDCl3) δ 9.27 (s, 1H), 8.70 (s, 1H), 8.60 (d, 1H, J=3.8 Hz), 8.37 (d, 1H, J=7.7 Hz), 7.52 (s, 1H), 7.39 (dd, 1H, J=4.6, 7.5 Hz), 7.01 (m, 2H), 6.96 (d, 1H, J=8.4 Hz), 6.79 (s, 1H), 4.5 (s, 2H), 3.2 (s, 3H).

Provenance & Evidence