4-methyl-3,4-dihydro-2H-1,4-benzoxazin-6-amine → N-tert-butyl-3-[2-(4-methyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylamino)-pyrrolo[2,1-f][1,2,4]triazin-7-yl]-benzenesulfonamide

Participants

Reaction Steps

The titled compound was prepared in analogous fashion as Example 113 using N-tert-butyl-3-(2-methanesulfinyl-pyrrolo[2,1-f][1,2,4]triazin-7-yl)-benzene sulfonamide and 4-methyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylamine to give N-tert-butyl-3-[2-(4-methyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylamino)-pyrrolo[2,1-f][1,2,4]triazin-7-yl]-benzenesulfonamide as a light tan foam (45.5 mg, 33% yield). LCMS (E/I+) 493 (M+H). 1H NMR (CDCl3; 400 MHz) δ 8.71 (s, 1H), 8.59 (s, 1H), 8.43 (d, 1H, J=8.0 Hz), 7.83 (d, 1H, J=8 Hz), 7.54 (t, 1H, J=8 Hz), 7.04 (d, 1H, J=4.8 Hz), 6.88 (m, 2H), 6.82 (m, 2H), 6.66 (s, 1H), 4.64 (s, 1H), 4.3 (t, 2H, J=4.4 Hz), 3.29 (t, 2H, J=4.4 Hz), 2.76 (s, 3H), 1.21 (s, 9H).

Provenance & Evidence