Trifluoroacetic acid → HCID 86761889, compound

Participants

Reaction Steps

The titled compound was prepared through an acid catalyzed deprotection using {6-[7-(3-tert-butylsulfamoyl-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-ylamino]-2-hydroxy-indan-1-yl}-carbamic acid tert-butyl ester and trifluoroacetic acid in methylene chloride to provide as a light brown lyophilate. LCMS (E/I+) 493 (M+H). 1H NMR (400 MHz, DMSO-d6) δ 9.64 (s, 1H), 9.05 (s, 1H), 8.50 (s, 1H), 8.45 (d, 1H, J=7.7 Hz), 8.38 (s, 3H), 7.88 (d, 1H, J=8.2 Hz), 7.83 (dd, 1H, J=7.8 Hz), 7.70 (t, 1H, J=7.8 Hz), 7.62 (broad s, 2H), 7.31 (d, 1H, J=8.3 Hz), 7.24 (d, 1H, J=4.7 Hz), 7.02 (d, 1H, J=4.7 Hz), 5.56 (s, 1H), 4.37 (s, 2H), 3.25 (dd, 1H, J=5.8, 16 Hz), 2.75 (d, 1H, J=16, 20 Hz), 1.11 (s, 9H).

Provenance & Evidence