2-Methanesulfinyl-7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazine → HCID 66711431, compound

Participants

Reaction Steps

Following the experimental procedure described in Example 753, 2-methanesulfinyl-7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazine and 2-methoxy-4-[4-(1-methyl-piperidin-4-yl)-perhydro-1,4-diazepin-1-yl]-phenylamine were converted to 2-methoxy-4-(1-{(S)-3,3,3-trifluoro-2-[7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-yloxy]-propyl}-piperidin-4-yl)-phenylamine as a yellow solid (61 mg, 46%). MP: 71-80° C.; 1H-NMR (CDCl3) δ 8.64 (s, 1H), 8.13 (d, J=8.7 Hz, 1H), 8.06 (d, J=7.6 Hz, 1H), 7.40 (m, 1H), 7.15 (s, 1H), 7.11 (m, 1H), 7.05 (d, J=8.4 Hz, 1H), 7.00 (d, J=2.5 Hz, 1H), 6.78 (d, J=3.2 Hz, 1H), 6.27 (s, 1H), 6.18 (d, J=8.8 Hz, 1H), 3.86 (s, 3H), 3.84 (s, 3H), 3.50 (br s, 4H), 2.87 (m, 4H), 2.64 (br s, 2H), 2.47 (m, 1H), 2.25 (s, 3H), 1.93 (m, 4H), 1.72 (m, 2H), 1.61 (m, 2H); LC/MS (ESI+): 542.3 (M+H).

Provenance & Evidence