HCID 66711841, compound → HCID 66711166, compound

Participants

Reaction Steps

To a solution of (±)-(3S,4S)-3,4-dihydroxy-4-(3-methoxy-4-nitro-phenyl)-piperidine-1-carboxylicacid tert-butyl ester (540 mg) in ethanol (30 mL) was added palladium on carbon 10% (78.00 mg). The mixture was shaken in a Parr apparatus under an atmosphere of hydrogen (˜max 25-30 PSI) for 5 h. Filtration through Celite and evaporation of the solvent provided (±)-(3S,4S)-4-(4-amino-3-methoxy-phenyl)-3,4-dihydroxy-piperidine-1-carboxylic acid tert-butyl ester in quantitative yield.

Provenance & Evidence