反应详情

1-acetyl-6-aminoindoline and (S)-1-[3-(2-Methanesulfinyl-pyrrolo[2,1-f][1,2,4]triazin-7-yl)-benzenesulfonyl]-pyrrolidin-3-ol were reacted in an analogous manner to Example 881D. The mixture was then taken up in DMSO and purified by Gilson prep HPLC to afford the product as a TFA salt (16 mg, 17%). HPLC purity=94%, rt=2.636 min, LCMS=519.2 (M+H). 1H NMR (400 MHz, (D3C)2SO, δ, ppm): 9.41 (s, 1H0, 9.01 (s, 1H), 8.58 (d, J=8.3 Hz, 1H), 8.31 (s, 1H), 8.26 (s, 1H0, 7.76 (d, J=8.1 Hz, 1H), 7.68 (dd, J=8.1 Hz, 8.1 Hz, 1H), 7.52 (dd, J=8.3 Hz, 1.8 Hz, 1H), 7.27 (d, J=4.7 Hz, 1H), 7.19 (d, J=8.3 Hz, 1H), 6.97 (d, J=4.9 Hz, 1H), 4.18-4.08 (m, 4H), 3.31-3.20 (m, 3H), 3.12-3.02 (m, 3H), 2.17 (s, 3H), 1.80-1.70 (m, 1H), 1.68-1.60 (m, 1H).

1. custompurified by Gilson prep HPLC