2-Methanesulfinyl-7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazine → HCID 66712465, compound

Participants

Reaction Steps

Following a procedure analogous to 251c, 7-methoxy-1′-methyl-3,4-dihydrospiro[chromene-2,4′-piperidin]-6-amine (0.15 g, 57 mmol) and 2-Methanesulfinyl-7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazine (55 mg, 19 mmol) were converted to the title compound (15 mgs, 13%) isolated as a TFA salt. H-NMR (DMSO-d6) δ 9.47 (broad s, 1H), 8.91 (s, 1H), 7.85-7.80 (m, 2H), 7.48-7.42 (m, 2H), 7.21 (d, J=9.2 Hz, 1H), 7.13-7.09 (m, 1H), 6.97-9.92 (m, 2H), 6.54 (s, 1H), 3.83 (s, 3H), 3.78 (s, 3H), 3.39-3.32 (m, 2H), 3.23-3.13 (m, 2H), 2.85 (s, 3H), 2.59-2.55 (m, 2H), 1.95-1.77 (m, 65H); LC/MS (ESI+): 486.18 (M+H).

Provenance & Evidence