3-(2-Morpholin-4-ylethoxy)aniline → HCID 66712313, compound

HRID 1262170Notes

Reaction equation

HRID 1262170 reaction equation
[N:1]1([CH2:7][CH2:8][O:9][C:10]2[CH:11]=[C:12]([NH2:16])[CH:13]=[CH:14][CH:15]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.CS([C:20]1[N:25]=[CH:24][C:23]2=[CH:26][CH:27]=[C:28]([C:29]3[CH:30]=[N:31][N:32]([CH3:34])[CH:33]=3)[N:22]2[N:21]=1)=O>>[CH3:34][N:32]1[CH:33]=[C:29]([C:28]2[N:22]3[C:23]([CH:24]=[N:25][C:20]([NH:16][C:12]4[CH:13]=[CH:14][CH:15]=[C:10]([O:9][CH2:8][CH2:7][N:1]5[CH2:6][CH2:5][O:4][CH2:3][CH2:2]5)[CH:11]=4)=[N:21]3)=[CH:26][CH:27]=2)[CH:30]=[N:31]1

Participants

3

Reactant 2

HCID 64866163-(2-Morpholin-4-ylethoxy)anilineHCID 667110872-Methanesulfinyl-7-(1-methyl-1H-pyrazol-4-yl)-pyrrolo[2,1-f][1,2,4]triazine

Product 1

HCID 66712313HCID 66712313, compound

Procedure

Prepared by following a procedure analagous to Example 251c by using 3-(2-Morpholin-4-yl-ethoxy)-phenylamine and 2-Methanesulfinyl-7-(1-methyl-1H-pyrazol-4-yl)-pyrrolo[2,1-f][1,2,4]triazine. 1H-NMR (DMSO) δ 10 (brs, 1H), 9.4 (s, 1H), 8.9 (s, 1H), 8.4 (s, 1H), 8.2 (s, 1H), 7.5 (brs, 1H), 7.3 (m, 2H), 7.06 (d, J=4.6 Hz, 1H), 6.9 (d, J=4.6 Hz, 1H), 6.7 (d, J=8.0 Hz, 1H), 4.3 (m, 2H), 4-3.1 (m, 10H), 3.9 (s, 3H); LC/MS (ESI+): 420 (M+H).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-54f29082d0b9409387e7cf1d10dda3c6
Source dataset
uspto-grants-2013_06
Patent number
US08471005B2

Reaction notes

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