3-[(1-Methylpyrrolidin-2-yl)methoxy]aniline → HCID 66712639, compound

HRID 1262172Notes

Reaction equation

HRID 1262172 reaction equation
[CH3:1][N:2]1[CH2:6][CH2:5][CH2:4][CH:3]1[CH2:7][O:8][C:9]1[CH:10]=[C:11]([NH2:15])[CH:12]=[CH:13][CH:14]=1.CS([C:19]1[N:24]=[CH:23][C:22]2=[CH:25][CH:26]=[C:27]([C:28]3[CH:29]=[N:30][N:31]([CH3:33])[CH:32]=3)[N:21]2[N:20]=1)=O>>[CH3:33][N:31]1[CH:32]=[C:28]([C:27]2[N:21]3[C:22]([CH:23]=[N:24][C:19]([NH:15][C:11]4[CH:12]=[CH:13][CH:14]=[C:9]([O:8][CH2:7][CH:3]5[CH2:4][CH2:5][CH2:6][N:2]5[CH3:1])[CH:10]=4)=[N:20]3)=[CH:25][CH:26]=2)[CH:29]=[N:30]1

Participants

3

Reactant 2

HCID 574160663-[(1-Methylpyrrolidin-2-yl)methoxy]anilineHCID 667110872-Methanesulfinyl-7-(1-methyl-1H-pyrazol-4-yl)-pyrrolo[2,1-f][1,2,4]triazine

Product 1

HCID 66712639HCID 66712639, compound

Procedure

Prepared by following a procedure analagous to Example 251c by using 3-(1-Methyl-pyrrolidin-2-ylmethoxy)-phenylamine and 2-Methanesulfinyl-7-(1-methyl-1H-pyrazol-4-yl)-pyrrolo[2,1-f][1,2,4]triazine. 1H-NMR (DMSO) δ 9.7 (brs, 1H), 9.4 (s, 1H), 8.9 (s, 1H), 8.4 (s, 1H), 8.2 (s, 1H), 7.5 (m, 1H), 7.3 (m, 2H), 7 (d, J=4.6 Hz, 1H), 6.9 (d, J=4.6 Hz, 1H), 6.6 (d, J=7.2 Hz, 1H), 4.3 (m, 1H), 4.2 (m, 1H), 3.9 (s, 3H), 3.8 (m, 1H), 3.6 (m, 1H), 3.1 (m, 1H), 2.9 (s, 3H), 2.2 (m, 1H), 2.0 (m, 1H), 1.9 (m, 1H), 1.8 (m, 1H); LC/MS (ESI+): 401 (M+H).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-c71d62b26b4846dc89ef0c5feb2da4e2
Source dataset
uspto-grants-2013_06
Patent number
US08471005B2

Reaction notes

Loading…