tert-Butyl 4-(5-aminopyridin-2-yl)piperidine-1-carboxylate → (1',2',3',4',5',6'-Hexahydro-[2,4']bipyridinyl-5-yl)-[7-(3-methanesulfonyl-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-yl]-amine

Participants

Reaction Steps

This example was prepared by using 5-Amino-3′,4′,5′,6′-tetrahydro-2′H-[2,4]bipyridinyl-1′-carboxylic acid tert-butyl ester (WO2006/047277) and 7-(3-Methanesulfonyl-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-ol as described in Example 1255c followed by deprotection as described in Example 1223. 1H-NMR (DMSO) δ 9.9 (s, 1H), 9.1 (s, 1H), 8.8 (s, 1H), 8.7 (s, 1H), 8.6 (brs, 1H), 8.4 (d, J=7.9 Hz, 2H), 8.2 (d, J=8.9 Hz, 1H), 8 (d, J=7.9 Hz, 1H), 7.8 (t, 1H), 7.3 (m, 2H), 7 (d, J=4.4 Hz, 1H), 3.4 (m, 2H), 3.36 (s, 3H), 3.0 (m, 3H), 2.0 (m, 2H), 1.85 (m, 2H); LC/MS (ESI+): 449 (M+H).

Provenance & Evidence