(7-Bromo-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-(4-morpholin-4-yl-phenyl)-amine → {7-[4-(1,1-Dioxo-1$1(6)-thiomorpholin-4-ylmethyl)-phenyl]-pyrrolo[2,1-f][1, 2,4]triazin-2-yl}-(4-morpholin-4-yl-phenyl)-amine

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Reaction Steps

{7-[4-(1,1-Dioxo-1$1(6)-thiomorpholin-4-ylmethyl)-phenyl]-pyrrolo[2,1-f][1,2,4]triazin-2-yl}-(4-morpholin-4-yl-phenyl)-amine was prepared from (7-bromo-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-(4-morpholin-4-yl-phenyl)-amine and 4-[(4-boronophenyl)methyl]-thiomorpholine 1,1-dioxide in an analogous manner to Example 1031b. Product isolated as a yellow solid (36 mg, 24%). m.p.=251-255° C.; LCMS (m/e) 519 (M+H); 1H-NMR (CDCl3, 400 MHz) δ 8.69 (s, 1H), 8.13 (d, 2H, J=7.8 Hz), 7.55 (d, 2H, J=7.4 Hz), 7.42 (d, 2H, J=7.8 Hz), 7.02-6.97 (m, 1H), 6.92 (d, 2H, J=7.0 Hz), 6.85-6.80 (m, 1H), 6.73-6.64 (m, 1H), 3.93-3.85 (m, 4H), 3.73 (s, 2H), 3.17-3.00 (m, 12H).

Provenance & Evidence