4-Bromo-1-methyl-1H-imidazole → [7-(1-Methyl-1H-imidazol-4-yl)-pyrrolo[2,1-f][1,2,4]triazin-2-yl]-(4-morpholin-4-yl-phenyl)-amine

Participants

Reaction Steps

[7-(1-Methyl-1H-imidazol-4-yl)-pyrrolo[2,1-f][1,2,4]triazin-2-yl]-(4-morpholin-4-yl-phenyl)-amine was prepared from 4-bromo-1-methyl-1H-imidazole and (4-morpholin-4-yl-phenyl)-[7-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrrolo[2,1-f][1,2,4]triazin-2-yl]-amine in an analogous manner to Example 1042b. Product isolated as a yellow foam (7 mg, 7%). LCMS (m/e) 376 (M+H); 1H-NMR (CDCl3, 400 MHz) δ 8.64 (s, 1H), 7.92 (d, 1H, J=1.2 Hz), 7.55 (d, 2H, J=8.9 Hz), 5.52 (s, 1H), 7.27 (d, 1H, J=4.8 Hz), 6.97 (d, 2H, J=8.9 Hz), 6.82 (d, 1H, J=4.8 Hz), 6.59 (bs, 1H), 3.93-3.87 (m, 4H), 3.76 (s, 3H), 3.18-3.13 (m, 4H).

Provenance & Evidence