5-Aminobenzimidazole → HCID 131730669, compound

Participants

Reaction Steps

(3H-Benzoimidazol-5-yl)-{7-[3-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-pyrrolo[2,1-f][1,2,4]triazin-2-yl}-amine was prepared from 7-[3-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-pyrrolo[2,1-f][1,2,4]triazin-2-ol and 3H-benzimidazol-5-ylamine in an analogous manner to Example 1052a. Product isolated as an orange solid (129 mg, 81%). m.p.=70-75° C.; LCMS (m/e) 471 (M+H); 1H-NMR (CDCl3, 400 MHz) δ 11.20-10.10 (m, 1H), 8.73 (s, 1H), 8.67-8.39 (m, 2H), 7.97 (s, 1H), 7.86-7.62 (m, 2H), 7.51-7.42 (m, 1H), 7.32 (d, 1H, J=7.5 Hz), 7.09-6.92 (m, 3H), 6.86 (d, 1H, J=4.7 Hz), 4.97 (s, 2H), 0.96 (s, 9H), 0.16 (s, 6H).

Provenance & Evidence